An Efficient One-Pot Synthesis of Bis (Indolyl)methanes Catalyzed by Ionic Liquid with Multi-SO H Groups under Ambient Temperature in Water
نویسندگان
چکیده
Ionic liquid with multi-SO H groups was employed as a catalyst for facile preparation of 3 bis(indolyl)methanes via the one-pot condensation of indole with aldehydes or ketones. Various aliphatic and aromatic aldehydes or ketones were utilized in the reaction and in all situations the desired product were synthesized successfully. The described novel synthesis method propose several advantages of safety, mild condition, short reaction times, high yields, simplicity and easy workup compared to the traditional method of synthesis.
منابع مشابه
An efficient green procedure for the synthesis of bis (indolyl) methanes in water
In this work, a green, simple and highly efficient procedure for the synthesis of bis(indolyl)methanes is described. The condensation of indoles with carbonyl compounds catalyzed by citric acid in water affords bis(indolyl)methanes in high yields and relatively short reaction times. The advantages of this method are using of water as a low cost solvent and efficient recyclability of the catalyst.
متن کاملEfficient synthesis of bis(indolyl)methanes catalyzed by (PhCH2PPh3)+Br- under solvent-free conditions
Benzyltriphenylphosphonium bromide (BTPB) has been applied as an efficient catalyst for the preparation of bis(indolyl)methanes (BIMs) via electrophilic substitution of indoles with aldehydes in the absence of solvent.
متن کاملIonic liquid N-ethylpyridinium hydrogen sulfate as an efficient catalyst for designing indole scaffolds and their antimicrobial behavior
Ionic liquid N-ethylpyridinium hydrogen sulfate has been prepared, characterized and used as an efficient recyclable catalyst for the synthesis of a series of indoles and bis(indolyl)methanes. Latter have been further explored for their potential antimicrobial activity against E coli and Bacillus. The ionic liquid used was recycled in the end and its recovery was facilitated b...
متن کاملIonic liquid N-ethylpyridinium hydrogen sulfate as an efficient catalyst for designing indole scaffolds and their antimicrobial behavior
Ionic liquid N-ethylpyridinium hydrogen sulfate has been prepared, characterized and used as an efficient recyclable catalyst for the synthesis of a series of indoles and bis(indolyl)methanes. Latter have been further explored for their potential antimicrobial activity against E coli and Bacillus. The ionic liquid used was recycled in the end and its recovery was facilitated b...
متن کاملPEG1000-Based Dicationic Acidic Ionic Liquid/Solvent-Free Conditions: An Efficient Catalytic System for the Synthesis of Bis(Indolyl)methanes
An efficient procedure has been researched for the solvent-free synthesis of bis(indolyl)methanes via a one-pot reaction of indoles and aldehydes or ketones promoted by PEG1000-based dicationic acidic ionic liquid (PEG1000-DAIL). The catalyst PEG1000-DAIL could be reused seven times with excellent results. Furthermore, through this method, a highly chemoselective reaction of benzaldehyde and ac...
متن کامل